Treatment of viral infections with a pyrimidine nucleoside

Details Treatment of viral infections with a pyrimidine nucleoside Treatment of viral infections with a pyrimidine nucleoside

A - Human Necessities

61

K

167/202

A61K 31/70 (2006.01) C07D 239/54 (2006.01)

Patent

CA 1335260

Treatments for viral infections are disclosed based on the finding that uridine can selectively protect and/or rescue uninfected cells, particularly human bone marrow progenitor cells, from the toxicity of pyrimidine nucleoside analogues during the treatment of retroviral diseases, such as AIDS, and that uridine phophorylase inhibitors are particularly effective in maintaining the necessary levels of uridine within such cells. A treatment for AIDS-type diseases is disclosed in which a pyrimidine nucleoside analogue and a uridine phosphorylase inhibitor are co-administered either simultaneously or sequentially to treat the viral infection and protect or rescue uninfected cells in the afflicted subject. This combination therapy also can be supplemented by direct administration of uridine.

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