Treatment of wounds using il-17b

Details Treatment of wounds using il-17b Treatment of wounds using il-17b

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2616831

IL-17B is known to stimulate the proliferation of chondrocytes, bone, and is highly expressed in nervous tissue, resulting in repair of diseased tissue. When IL-17B is absent a marked negative effect on wound healing is noted. The present invention comprises providing IL-17B, by topical, parental, or other administration means, in order to accelerate the wound healing process. The present invention further encompasses a pharmaceutical composition and formulations thereof that utilize IL-17B, either alone or in combination with other cytokines or growth factors known to aid wound healing. The invention also contemplates methods of treating wounds in patients using this pharmaceutical composition.

On sait que l'interleukine IL-17B stimule la prolifération des chondrocytes et des os et est fortement exprimée dans les tissus nerveux, entraînant ainsi la réparation de tissus malades. On note l'effet négatif marqué que l'absence d'IL-17B a sur la cicatrisation. Aussi l'invention concerne-t-elle un procédé consistant à fournir de l'IL-17B, par des moyens d'administration topiques, parentéraux ou autres, afin d'accélérer le processus de cicatrisation. L'invention concerne également une composition pharmaceutique et des formulations de celle-ci qui utilisent l'IL-17B, seule ou en combinaison avec d'autres cytokines ou facteurs de croissance connus pour faciliter la cicatrisation. L'invention concerne en outre des procédés pour le traitement de plaies chez des patients au moyen de cette composition pharmaceutique.

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