Treatment or prophylaxis of insulin-producing cell graft...

Details Treatment or prophylaxis of insulin-producing cell graft... Treatment or prophylaxis of insulin-producing cell graft...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/133 (2006.01) A61K 31/365 (2006.01) A61K 31/436 (2006.01) A61K 39/00 (2006.01) A61K 45/06 (2006.01) A61P 5/50 (2006.01)

Patent

CA 2445605

A pharmaceutical combination comprising an accelerated lymphocyte homing agent in free form or in pharmaceutically acceptable salt form, and one or more compounds selected from the group consisting of an antibody to the IL-2 receptor, an immunosuppressive macrocylic lactone and a soluble human complement inhibitor is used to treat or prevent insulin-producing cell graft rejection.

La présente invention concerne une combinaison pharmaceutique qui renferme un agent d'écotaxie lymphocytaire accélérée sous forme libre ou sous forme de sel pharmaceutiquement acceptable et un ou plusieurs composés sélectionnés dans le groupe formé par un anticorps dirigé contre le récepteur IL-2, une lactone macrocyclique immunosuppressive et un inhibiteur complémentaire humain soluble. Cette combinaison pharmaceutique est utilisée pour traiter ou prévenir le rejet des greffes de cellules produisant de l'insuline.

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