Treatment or replacement therapy using transgenic stem cells...

Details Treatment or replacement therapy using transgenic stem cells... Treatment or replacement therapy using transgenic stem cells...

A - Human Necessities

61

K

A61K 35/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/22 (2006.01) A61K 38/28 (2006.01) A61K 48/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 15/08 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/79 (2006.01)

Patent

CA 2452707

The present invention is directed to methods for hormone delivery to patients suffering from a condition associated with a hormone deficiency. The method involves transducing stem cells, such as bone marrow derived stem cells, with a hormone gene under the control of a cell-type specific promoter such as the glucose-responsive GIP promoter, such that the hormone gene is expressed only after the stem cells differentiate into the cells which express the cell-type specific promoter, and administering the stem cells to the patient. A preferred embodiment of the present invention is the use of GIP-insulin gene expression in K cells of the gut to treat diabetes.

La présente invention concerne des procédés d'administration d'hormones à des patients souffrant d'une maladie associée à une déficience hormonale. Le procédé consiste à transduire des cellules souches, telles que des cellules souches dérivées de la moelle osseuse, avec un gène d'hormone sous le contrôle d'un promoteur spécifique de type cellule, tel que le promoteur GIP répondant au glucose, de telle sorte que le gène d'hormone soit exprimé uniquement après que les cellules souches se différencient en cellules exprimant le promoteur spécifique de type cellule, puis à administrer les cellules souches au patient. Dans un mode de réalisation préféré, on utilise l'expression du gène de l'insuline GIP dans des cellules K de l'intestin pour traiter le diabète.

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