Treatment, prevention and amelioration of pulmonary...

A - Human Necessities – 61 – K

Patent

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A61K 31/59 (2006.01) C07C 401/00 (2006.01)

Patent

CA 2606517

The present invention relates to a method for preventing, treating or ameliorating pulmonary disorders in a patient receiving a chemotherapeutic or radiotherapeutic agent or treatment comprising administering to the patient a pharmaceutical composition comprising an effective amount of active vitamin D compound or a mimic thereof. According to the invention, the active vitamin D compound, or the mimic thereof, may be administered by HDPA so that high doses of the active vitamin D compound can be administered to an animal without inducing severe symptomatic hypercalcemia.

L'invention concerne une méthode servant à prévenir, traiter ou améliorer des maladies pulmonaires chez un patient soumis à un traitement ou à un agent chimiothérapeutique ou radiothérapeutique, ce qui consiste à administrer à ce patient une composition pharmaceutique contenant une quantité efficace d'un composé actif de vitamine D ou un de ses analogues. Selon l'invention, on peut administrer ce composé actif de vitamine D ou son analogue par HDPA, de manière à pouvoir administrer des doses élevées de ce composé actif de vitamine D à l'animal sans induire d'hypercalcémie symptomatique grave.

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