Treatment with gemcitabine and an egfr-inhibitor

Details Treatment with gemcitabine and an egfr-inhibitor Treatment with gemcitabine and an egfr-inhibitor

A - Human Necessities

61

K

A61K 31/513 (2006.01) A61K 31/4706 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2567836

The present invention provides a method for manufacturing a medicament for treating tumors or tumor metastases, characterized in that a therapeutically effective amount of an EGFR kinase inhibitor and gemcitabine is used, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and gemcitabine combination in combination with a pharmaceutically acceptable carrier. A preferred example of an EGFR kinase inhibitor that can be used in practising this invention is the compound erlotinib HCl (also known as TarcevaTM).

La présente invention se rapporte à un procédé de fabrication d'un médicament permettant de traiter des tumeurs ou des métastases tumorales, qui se caractérise en ce qu'une quantité thérapeutiquement efficace d'un inhibiteur de kinase d'EGFR et de gemcitabine est utilisé, avec ou sans agents ou traitements supplémentaires, tels que d'autres médicaments anticancéreux ou une radiothérapie. L'invention se rapporte également à une composition pharmaceutique qui comporte une combinaison de gemcitabine et d'un inhibiteur de kinase d'EGFR en association à un excipient pharmaceutiquement acceptable. Un exemple préféré d'inhibiteur de kinase d'EGFR pouvant être utilisé pour mettre en oeuvre cette invention et le composé erlotinib HC1 (également connu comme Tarceva<SP>TM</SP>).

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