Treatments for neuropathy

Details Treatments for neuropathy Treatments for neuropathy

A - Human Necessities

61

K

A61K 31/4706 (2006.01) A61K 31/47 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2714676

Small fiber neuropathy is treated or prevented by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat or prevent neuropathy in the subject. Glial cell- derived neurotrophic factor (GDNF) receptors are modulated with the subject active quinoline compounds, which may be formulated in topical lotions.

Cette invention concerne la neuropathie des petites fibres traitée ou prévenue par administration topique chez un sujet de composés de quinoline active ou de leurs sels pharmaceutiquement acceptables dans des conditions efficaces pour traiter ou prévenir la neuropathie chez le sujet. Les récepteurs du facteur GDNF (facteur neurotrophique dérivé des cellules gliales) sont modulés avec les composés de quinoline active, qui peuvent être préparés sous forme de lotions topiques.

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