A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/34 (2006.01) A46B 9/02 (2006.01) A61K 31/00 (2006.01) A61K 31/34 (2006.01) A61K 31/4745 (2006.01) A61K 38/10 (2006.01) A61K 45/06 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 15/12 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2332169
The present invention provides a method of treating obesity, sexual dysfunction (including erectile dysfunction), diabetes, insulin resistance, hyperinsulinemia, Syndrome X, adrenal dysfunction, hypertension, hypercholesterolemia, atherosclerosis, hyperlipoproteinemia, hypertriglyceridemia, or substance abuse, the method comprising the step of administering to a patent having or at risk of having one of the above-mentioned diseases a therapeutically effective amount of a compound that attenuates the binding of agouti-related protein to melanocortin receptors, but does not attenuate the binding of .alpha.- melanocyte stimulating hormone to melanocortin receptors. The present invention also provides a method of identifying a compound that is useful for the treatment or prevention of obesity, sexual dysfunction (including erectile dysfunction), diabetes, insulin resistance, hyperinsulinemia, Syndrome X, adrenal dysfunction, hypertension, hypercholesterolemia, atherosclerosis, hyperlipoproteinemia, hypertriglyceridemia, or substance abuse, the method comprising the steps of: 1) determining if a compound affects the binding of agouti-related protein to melanocortin receptors; 2) determining if a compound affects the binding of .alpha.-melanocyte stimulating hormone to melanocortin receptors; and 3) selecting a compound that attenuates the binding of agouti-related protein to melanocortin receptors, but does not affect the binding of .alpha.- melanocyte stimulating hormone to melanocortin receptors.
Hadcock John Richard Neville
Swick Andrew Gordon
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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