Treatments with autologous fibroblast

C - Chemistry – Metallurgy – 12 – N

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C12N 5/00 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2485567

The invention provides compositions containing autologous, passaged fibroblasts and, optionally, autologous, passaged muscle cells, biodegradable acellular matrix components, and/or biodegradable acellular fillers, The invention also provides methods for making the compositions, as well as devices and methods for administering the compositions to treat conditions such as urinary incontinence, vesicoureteral reflux, and gastroesophageal reflux.

La présente invention concerne des compositions contenant des fibroblastes ayant subi des passages, autologues, et, éventuellement, des cellules musculaires ayant subi des passages, autologues, des composants de matrices acellulaires biodégradables et/ou des charges acellulaires biodégradables. L'invention concerne également des procédés de fabrication desdites compositions, ainsi que des dispositifs et des procédés d'administration desdites compositions afin de traiter des états pathologiques tels que l'incontinence urinaire, le reflux vésico-urétéral et le reflux gastro-oesophagien.

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