Trefoil factor 3 (tff3) as a target for anti-cancer therapy

Details Trefoil factor 3 (tff3) as a target for anti-cancer therapy Trefoil factor 3 (tff3) as a target for anti-cancer therapy

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 31/7105 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C07K 5/08 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/579 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2534658

The present invention is directed to methds of treating and preventing cancer, such as cancer characterized by differential expression of trefoil factor 3 (TFF3). The methods include administering to a patient an agent that modulates TFF3 activity or expression. The present invention is further directed to reducing the physiological effects of TFF3 expression in cells, including inhibiting cell motility and resistance to apoptosis. Oligonucleotides and antibodies that can modulate expression or activity of TFF3 are also provided.

L'invention concerne des méthodes de prévention et de traitement des cancers se caractérisant par une expression différentielle du peptide en trèfle TFF3. Les méthodes selon l'invention consistent à administrer à un patient un agent modulant l'activité ou l'expression du TFF3. La présente invention concerne également l'atténuation des effets physiologiques de l'expression du TFF3 dans des cellules, notamment de l'inhibition de la motilité cellulaire et de la résistance à l'apoptose. L'invention concerne encore des oligonucléotides et des anticorps pouvant moduler l'expression ou l'activité du TFF3.

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