C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/50 (2006.01) A61K 31/506 (2006.01) C07C 205/06 (2006.01) C07C 225/20 (2006.01) C07C 225/22 (2006.01) C07C 229/34 (2006.01) C07C 229/38 (2006.01) C07C 229/42 (2006.01) C07C 233/36 (2006.01) C07C 255/58 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2692702
The invention relates to tri-amino-pyrimidine derivatives of the general formula (I) in which Y, R3, W, R4a, R5a, R4b, R5b, n and m are variable. These compounds have a phosphatase CDC25 inhibiting activity and can thus be used as drugs for diseases in which CDC25 are involved. The invention also relates to pharmaceutical compositions containing said products, and to the use thereof for preparing a drug.
La présente invention a pour objet des dérivés tri-amino-pyrimidine de formule générale (I) dans laquelle Y, R3, W, R4a, R5a, R4b, R5b, n et m sont variables. Ces composés présentent une activité inhibitrice des phosphatases CDC25 et sont donc susceptibles d'être utilisés comme médicaments dans les pathologies dans lesquelles les CDC25 sont impliquées. L'invention concerne également des compositions pharmaceutiques contenant lesdits produits et leur utilisation pour la préparation d'un médicament.
Bigg Dennis
Brezak Pannetier Marie-Christine
Liberatore Anne-Marie
Pons Dominique
Prevost Gregoire
Goudreau Gage Dubuc
Ipsen Pharma S.a.s.
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