Tri- and tetra-valent monospecific antigen-binding proteins

Details Tri- and tetra-valent monospecific antigen-binding proteins Tri- and tetra-valent monospecific antigen-binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07C 237/16 (2006.01) C07D 207/452 (2006.01) C07D 257/02 (2006.01) C07D 403/12 (2006.01) C07K 1/107 (2006.01) C07K 5/02 (2006.01) C07K 5/08 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2088367

The invention provides a tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other covalently by a connecting structure, which protein is not a natural immunoglobuline. Further provided are novel connecting structures for use in assembling the proteins of the invention and means for attaching a labeling or effector group thereto. The proteins of the invention are useful, for example, in the treatment and diagnosis of cancer.

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