Tri-and tetraaza-acenaphthylen derivatives as crf receptor...

Details Tri-and tetraaza-acenaphthylen derivatives as crf receptor... Tri-and tetraaza-acenaphthylen derivatives as crf receptor...

C - Chemistry, Metallurgy

07

D

C07D 471/16 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 209/00 (2006.01) C07D 211/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2450535

CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure of formula (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, R1, R2, R4, R5, R6, A, X, and Y are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

La présente invention concerne des antagonistes du récepteur CRF qui conviennent pour le traitement de divers troubles, notamment le traitement de troubles se manifestant par une hypersécrétion de CRF chez des animaux à sang chaud, tels que l'apoplexie. La structure des antagonistes du récepteur CRF de cette invention est représentée par la formule (I). Cette structure comprend des isomères, des promédicaments et des sels de ceux-ci répondant aux normes pharmaceutiques. Dans cette formule, R1, R2, R4, R5, R6, A, X, et Y sont tels que définis dans les spécifications. Cette invention concerne aussi des compositions contenant un antagoniste de récepteur CRF associé à un porteur répondant aux normes pharmaceutiques, ainsi que des techniques d'utilisation de ces compositions.

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