C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/06 (2006.01) A61K 38/28 (2006.01) C07K 14/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2083360
Abstract This invention relates to human insulin analogs (tri-arg insulins) and includes two enzymatic methods for producing tri-arg insulins. These compounds can be formulated as a soluble entity up to pH 6.1 and have prolonged hypoglycemic activity. Tri-arg insulins have the basic structure of natural human insulin plus three additional arginine residues. Two of the three additional Arg residues are located in tandem at the carboxy terminus of the insulin B-chain, and the third Arg residue is located at the amino terminus of the insulin A-chain. Tri- arg insulin analogs, having certain amino acid substitutions at the B3, B10 and A21 positions, are within the instant invention.
Hoffmann James A.
Lambooy Peter K.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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