Tri-block copolymers for nanosphere-based drug delivery

Details Tri-block copolymers for nanosphere-based drug delivery Tri-block copolymers for nanosphere-based drug delivery

C - Chemistry, Metallurgy

08

G

C08G 64/18 (2006.01) A61K 47/34 (2006.01) C08G 65/04 (2006.01) C08G 81/00 (2006.01) C08L 69/00 (2006.01) C08L 71/02 (2006.01) C08G 69/44 (2006.01) C08L 77/12 (2006.01)

Patent

CA 2616810

Biocompatible non-toxic triblock copolymers having an A-B-A structure wherein each A is a hydrophilic, biocompatible end block and the B middle block is a hydrophobic desaminotyrosyl tyrosine polycarbonate or polyarylate. The copolymers spontaneously self~assemble to form low critical aggregation concentration nanospheres having utility as delivery vehicles for hydrophobic biologically or pharmaceutically active compounds.

L'invention concerne des copolymères triblocs non toxiques biocompatibles de structure A-B-A dans laquelle A représente un bloc d'extrémité biocompatible, hydrophile, et B le bloc intermédiaire hydrophobe desaminotyrosyl tyrosine polycarbonate ou polyarylate. Les copolymères s'assemblent spontanément pour former des nanosphères à concentration d'agrégation critique faible qui sont utiles comme vecteurs d'administration de composés hydrophobes biologiquement ou pharmaceutiquement actifs.

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