Tri-block polymers for nanosphere-based drug or gene delivery

Details Tri-block polymers for nanosphere-based drug or gene delivery Tri-block polymers for nanosphere-based drug or gene delivery

C - Chemistry, Metallurgy

08

G

C08G 63/00 (2006.01) A61K 47/48 (2006.01) A61M 31/00 (2006.01) C08G 63/06 (2006.01) C08G 69/44 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2486104

Biocompatible non-toxic polyarylate triblock copolymers having an A-B-A structure wherein each A is a water-soluble, hydrophilic polymer end block and the B middle block is an polyarylate oligomer. The polymers spontaneously self- assemble to form low CAC nanospheres having utility as transfection agents for gene delivery.

L'invention concerne des copolymères triblocs polyarylate non toxiques, biocompatibles de structure A-B-A dans laquelle chaque A représente un bloc d'extrémité de polymère hydrophile, hydrosoluble, B représentant la séquence du milieu sous forme d'oligomère polyarylate. Les polymères s'assemblent spontanément afin de former des nanosphères à concentration d'agrégation critique faible dotés d'une utilité en tant qu'agents de transfection pour l'administration de gène.

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