C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/100, 167/139
C12N 11/00 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) G01N 33/543 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2037835
H-7912 ABSTRACT The present invention has multiple aspects. In its first aspect the present invention is directed to a trifunctional antibody-like compound that has tissue, organ, cell or molecule specificity and which is capable of being bifunctional when immobilized, via binding, at the tissue, organ, cell or molecule for which it has specificity. In particular, the present invention is directed to a trifunctional antibody-like compound of Formula 1: Image (I) wherein L is one or two moieties for cross-linking F1ab', F2ab' and F3ab'; wherein F1ab' is an Fab'-like fragment of a polyclonal or monoclonal antibody having specificity for an antigen expressed by the organ, tissue, cell or molecule of interest; wherein F2ab' is an Fab'-like fragment of a polyclonal or monoclonal antibody having the same specificity as F1ab', or having specificity either for a different antigen expressed by the organ, tissue, cell, or molecule of interest, or for a diagnostic or therapeutic agent; and wherein F3ab' is an Fab'-like fragment of a polyclonal or monoclonal antibody having specificity for a diagnostic or therapeutic agent; or wherein F2ab' and F3ab' have specificity for a receptor/receptor complex and accessory molecule on the surface of a T-cell. The compound of the present invention has utility as a pharmaceutical agent. Various methods for treating and diagnosing a disease are also presented.
Ahlem Clarence N.
Huang Ann E.
Gowling Lafleur Henderson Llp
Hybritech Incorporated
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