C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 9/02 (2006.01)
Patent
CA 2439492
The present invention relates to novel tri-hybrid melanoma antigens, including antigenic fragments or derivatives thereof, of a tyrosinase (TYR) antigen, a tyrosinase-related protein 1 (TRP-1) antigen, and a tyrosinase-related protein 2 (TRP-2) antigen and nucleic acids encoding them. The novel tri-hybrid melanoma antigens of the present invention are useful in the diagnosis, treatment and prevention of human neoplasms, including malignant tumors, such as carcinomas, sarcomas, leukemia, and lymphomas, and pre-malignant lesions, such as adenomas and dysplastic lesions.
La présente invention concerne de nouveaux antigènes du mélanome trihybrides, comprenant des fragments antigéniques ou des dérivés de ces derniers, d'un antigène de la tyrosinase (TYR), un antigène de la protéine 1 liée à la tyrosinase (TRP-1), et un antigène de la protéine 2 liée à la tyrosinase (TRP-2) et des acides nucléiques les codant. Ces nouveaux antigènes du mélanome trihybrides sont utiles dans le diagnostic, le traitement et la prévention des néoplasmes humains, y compris les tumeurs malignes, telles que les carcinomes, les sarcomes, la leucémie et les lymphomes, et les lésions précancéreuses, telles que les adénomes et les lésions dysplasiques.
Hicklin Daniel J.
Kang Xiaoqiang
Imclone Systems Incorporated
Smart & Biggar
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