Tri-iodated isophthalic acid diamides as non-ionic x-ray...

Details Tri-iodated isophthalic acid diamides as non-ionic x-ray... Tri-iodated isophthalic acid diamides as non-ionic x-ray...

C - Chemistry, Metallurgy

07

C

260/550.5

C07C 233/00 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01)

Patent

CA 1130316

ABSTRACT OF THE DISCLOSURE The invention provides compounds of the general formula Image (I) in which The amide radicals -CO-NR1R2 and -CO-NR3R4 are different from one another, and R1 represents a hydrogen atom or a lower alkyl radical, R2 represents a mono- or poly-hydroxyalkyl radical, R3 represents a hydrogen atom or a lower alkyl radical, R4 represents a mono- or poly-hydroxyalkyl radical, R5 represents a lower alkyl radical or a lower alkyl radi- cal substituted by 1 or more of the same or different substi- tuents selected from hydroxy groups and lower alkoxy radicals, R6 represents a hydrogen atom, a lower alkyl radical or a mono- or poly-hydroxy-lower alkyl radical, useful as X-ray contrast agents, especially for intravascular, subarachnoidal and local application.

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