Tri-substituted heteroaryls and methods of making and using...

Details Tri-substituted heteroaryls and methods of making and using... Tri-substituted heteroaryls and methods of making and using...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/36 (2006.01) A61K 31/395 (2006.01) A61K 31/435 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61K 31/517 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 453/00 (2006.01) C07D 471/04 (2006.01) C07D 487/08 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2480860

Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).

L'invention concerne des composés représentés par la formule (I) qui présentent une affinité étonnamment élevée pour Alk 5 et/ou Alk 4, et qui peuvent être utiles en tant qu'antagonistes pour la prévention et/ou le traitement de nombreuses. Dont des pathologies fibreuses. Dans un mode de réalisation, l'invention concerne un composé de formule générale (I).

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