C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/30 (2006.01) A61K 31/09 (2006.01) A61K 31/33 (2006.01) C07C 43/235 (2006.01) C07C 43/247 (2006.01) C07C 69/94 (2006.01) C07C 205/35 (2006.01) C07C 255/54 (2006.01) C07D 207/333 (2006.01) C07D 213/61 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 217/22 (2006.01) C07D 237/08 (2006.01) C07D 239/24 (2006.01) C07D 239/26 (2006.01) C07D 239/28 (2006.01) C07D 239/38 (2006.01) C07D 239/42 (2006.01) C07D 307/42 (2006.01) C07D 333/16 (2006.01)
Patent
CA 2126072
Compounds are described in formula (1), wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; R2 is an optionally substituted cycloalkyl or cycloalkenyl group; R3 is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, nitrogen or sulphur atoms or a group -N(R4)- where R4 is a hydrogen atom or an alkyl group; X is -O-, -S-, or -N(R5)-, where R5 is a hydrogen atom or an alkyl group; with the proviso that when X is -O- the R3 is not a 3-cyanamimo-6-pyridazinyl or a 3-chloro-6-pyridazinyl group; and the salts, solvates, hydrates and N- oxides thereof. The compounds are selective phosphodiesterase IV inhibitors and are useful for the prophylaxis or treatment of inflammatory diseases.
Boyd Ewan Campbell
Eaton Michael Anthony William
Warrellow Graham John
Celltech Limited
Celltech Therapeutics Limited
Kirby Eades Gale Baker
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