C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2564587
The present invention relates to 1,1,3-tri-substituted ureas having the formula (I) wherein R, R1 and R2 are as defined in the claims which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1,1,3-tri- substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.
La présente invention a trait à des urées 1,1,3-trisubstituées de formule (I), dans laquelle: R, R?1¿ et R?2¿ sont tels que définis dans les revendications, inhibitrices de la libération extracellulaire de cytokines inflammatoires, lesdites cytokines étant responsables pour un ou plusieurs états de maladie humains ou de mammifères supérieurs. La présente invention a également trait à des compositions comportant des urées 1,1,3-trisubstituées inhibitrices de la libération extracellulaire de cytokines inflammatoires, et à des procédés pour la prévention, l'atténuation, ou d'autres types de contrôle d'enzymes connues pour être des constituants actifs responsables desdits états de maladie.
Brugel Todd Andrew
Clark Michael Philip
De Biswanath
Golebiowski Adam
Sabat Mark
The Procter & Gamble Company
Torys Llp
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