Tri-, tetra-, penta-, and polypeptides and their therapeutic...

Details Tri-, tetra-, penta-, and polypeptides and their therapeutic... Tri-, tetra-, penta-, and polypeptides and their therapeutic...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 25/24 (2006.01) C07K 5/097 (2006.01) C07K 5/10 (2006.01) C07K 5/107 (2006.01) C07K 5/117 (2006.01)

Patent

CA 2189145

The present invention discloses novel peptides utilized to treat patients suffering from depression. These novel peptides are modifications of the tripeptide hormone MIF, including modification of amino terminus residues, carboxyl terminus residues and internal residues, including addition and substitution of amino acid residues and modification of the peptide bonds and functional side groups of respective amino acid residues. The tri-, tetra-, penta-, peptides and polypeptides of the present invention may be utilized alone or in combination to treat patients suffering from depression.

L'invention concerne des nouveaux peptides utilisés pour traiter des patients souffrant de dépression. Ces nouveaux peptides sont le fruit de modifications de l'hormone tripeptidique MIF, dont la modification des restes d'extrémités terminales amino, carboxyle et des restes internes, ainsi que l'addition et la substitution de restes d'acides aminés et la modification des liaisons peptidiques ainsi que des groupes latéraux fonctionnels des restes d'acides aminés respectifs. Les tri-, tétra-, penta peptides et polypeptides de l'invention peuvent être utilisés seuls ou combinés pour traiter des patients souffrant de dépression.

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