C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/54 (2006.01) A61K 31/135 (2006.01) A61K 31/235 (2006.01) A61K 31/33 (2006.01) C07C 215/42 (2006.01) C07C 217/52 (2006.01) C07C 219/24 (2006.01) C07D 215/06 (2006.01) C07D 215/42 (2006.01) C07D 307/79 (2006.01) C07D 307/82 (2006.01) C07D 311/58 (2006.01) C07D 311/68 (2006.01) C07D 333/78 (2006.01) C07D 333/80 (2006.01) C07D 335/06 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2105560
ABSTRACT A trialkylamine derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof: Image (1) [wherein R1 and R2 may be the same or different from each other and each represents lower alkyl; R3, R4 and R5 may be the same or different from one another and each represents hydrogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl or halogen; R6 and R7 may be the same or different from each other and each represents hydrogen or lower alkyl; R8 represents hydrogen, lower alkyl, lower alkoxy or halogen; X represents oxygen, sulfur, -CH=N- or -CH=CH-; Y represents oxygen, sulfur, methylene, N-R11 (wherein R11 represents lower alkyl), SO or SO2; Z represents -OCO(CH2)p- or -OCH2(CH2)p- (wherein p represents a number of 0 to 4 and symbol - represents the linkage with a benzene ring); and m and n represent each a number of 0 to 3 and the sum of m and n is 3 or less, provided that the case where m is 0, n is 1 or 2, R1 and R2 represent each methyl, X represents -CH=CH-, Y represents -CH2-, and Z represents -O-CO- is excluded]. These compounds have an excellent activity of ameliorating for gastrointestinal motility and hence are widely utilized in the treatment of gastrointestinal diseases.
Chaki Kyoji
Ichikawa Hiromi
Muto Yoshiaki
Ogura Kuniyoshi
Seiki Masao
Gowling Lafleur Henderson Llp
Zeria Pharmaceutical Co. Ltd.
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