Triaryl and diaryl compounds, their analogues and uses thereof

Details Triaryl and diaryl compounds, their analogues and uses thereof Triaryl and diaryl compounds, their analogues and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 22/04 (2006.01) A61K 31/00 (2006.01) A61K 31/02 (2006.01) A61K 31/075 (2006.01) A61K 31/095 (2006.01) A61K 31/11 (2006.01) A61K 31/13 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) C07C 15/16 (2006.01) C07C 17/35 (2006.01) C07C 25/18 (2006.01) C07C 33/24 (2006.01) C07C 33/34 (2006.01) C07C 33/46 (2006.01) C07C 39/367 (2006.01) C07C 43/164 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 45/00 (2006.01) C07C 45/44 (2006.01) C07C 47/23 (2006.01) C07C 47/273 (2006.01) C07C 49/215 (2006.01)

Patent

CA 2250092

The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. The compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

La présente invention porte sur une classe de composés chimiques utiles comme médicaments actifs dans le traitement de la drépanocytose ou des maladies caractérisées par une prolifération anormale ou non désirée de cellules. Les composés actifs sont des composés de triaryle méthane substitué ou leurs analogues où un ou plusieurs groupe aryle est remplacé par un groupe hétéroaryle, cycloalkyle ou hétérocycloalkyle et/ou le carbone tertiaire est remplacé par un atome différent tel que Si, Ge, N ou P. Lesdits composés inhibent la prolifération des cellules de mammifères, inhibent le canal de Gardos des érythrocytes, réduisent la déshydratation des érythrocytes falciformes et/ou retardent l'apparition de la falciformation ou de la déformation des érythrocytes.

Affiliated with

Also associated with

Rating

Triaryl and diaryl compounds, their analogues and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triaryl and diaryl compounds, their analogues and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triaryl and diaryl compounds, their analogues and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1996155