C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/10 (2006.01) A61K 31/505 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01)
Patent
CA 2483075
The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6- trione metalloproteinase inhibitors of the formula (I) wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G and W are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.
La présente invention se rapporte à des inhibiteurs de la triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione métalloprotéinase de formule (I) dans laquelle l'anneau X désigne un anneau hétérocyclique à 5-7 éléments et dans laquelle A, Y, B, G et W sont tels que définis dans le descriptif. L'invention se rapporte également à des compositions pharmaceutiques et à des méthodes de traitement d'inflammations, du cancer, et d'autres troubles.
Freeman-Cook Kevin Daniel
Noe Mark Carl
Pfizer Products Inc.
Sim & Mcburney
LandOfFree
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