Triarylmethane analogs and their use in treating cancers

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 223/28 (2006.01) A61K 31/00 (2006.01) A61P 35/00 (2006.01) C07C 211/56 (2006.01) C07C 233/55 (2006.01) C07C 251/30 (2006.01) C07D 215/26 (2006.01) C07D 215/46 (2006.01) C07D 225/08 (2006.01) C07D 263/32 (2006.01) C07D 275/06 (2006.01) C07F 9/145 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2711221

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.

La présente invention concerne des composés, des compositions pharmaceutiques comprenant les composés et des procédés de préparation et d'utilisation correspondants. Les composés sont des analogues de triphénylméthane. Les composés et les compositions peuvent être utilisés pour traiter et/ou prévenir une grande diversité de cancers, y compris les cancers résistant aux médicaments, les maladies inflammatoires, dégénératives et vasculaires, y compris diverses maladies oculaires et infections parasitaires. Des analogues de triphénylméthane représentatifs comprennent des analogues de triphénylméthane de divers colorants, hormones, sucres, peptides, oligonucléotides, acides aminés, nucléotides, nucléosides et polyols. Ces composés sont supposés fonctionner par inhibition de l'expression tNOX, des effets de ROS, et/ou de la production de HIF2. Par conséquent, ces composés sont de nouveaux agents thérapeutiques destinés à divers cancers et diverses autres maladies.

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