Triazaspiro[5.5]undecane derivative and pharmaceutical...

Details Triazaspiro[5.5]undecane derivative and pharmaceutical... Triazaspiro[5.5]undecane derivative and pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/503 (2006.01) A61K 31/5377 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/04 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 27/14 (2006.01) A61P 29/00 (2006.01) A61P 35/04 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2440264

Triazaspiro[5.5]undecane derivatives represented by the general formula (I), quaternary ammonium salts thereof, N-oxides thereof, nontoxic salts thereof, and drugs containing the same as the active ingredient (wherein R1 represents a group of the formula (II) or (III); R2 represents alkyl, alkynyl, etc.; R3 and R4 represent each H, optionally substituted alkyl, etc., or R3 and R4 may form together a group of the formula (IV); and R5 represents H or alkyl. Because of inhibiting the effects of chemokine/chemokine receptor, the compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, etc.

L'invention concerne des dérivés de triazaspiro[5.5] undécane représentés par la formule générale (I), leurs sels d'ammonium quaternaires, leurs N-oxydes, leurs sels non toxiques ainsi que des médicaments les contenant en tant que principe actif (formule dans laquelle R?1¿ représente un groupe de la formule (II) ou (III); R?2¿ représente alkyle, alkynyle, etc.; R?3¿ et R?4¿ représentent chacun H, alkyle facultativement substitué, etc., ou R?3¿ ainsi que R?4¿ peuvent former ensemble un groupe de la formule (IV); et R?5¿ représente H ou alkyle). Etant donné qu'ils inhibent les effets de la chimiokine / du récepteur de chimiokine, les composés représentés par la formule générale (I) sont utiles dans la prévention et/ou le traitement de diverses maladies inflammatoires, l'asthme, la dermatite atopique, l'urticaire, les maladies allergiques, la néphrite, la néphropathie, l'hépatite, l'arthrite, la polyarthrite rhumatoïde, etc.

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