C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/527 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/18 (2006.01) A61P 35/04 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2497903
A compound represented by the following general formula (I): (I) wherein each symbol is as defined in the description; its quaternary ammonium salt, its N- oxide or a salt thereof. Compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immune diseases (autoimmune disease, transplant rejection, immune suppression, psoriasis, multiple sclerosis, etc.), infection with human immunodeficiency virus (acquired immune deficiency syndrome), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis, etc.
L'invention concerne un composé représenté par la formule générale (I) dans laquelle chaque symbole est tel que défini dans la description, son sel d'ammonium quaternaire, son N-oxyde ou un sel de celui. Les composés représentés par la formule générale (I) sont utiles dans la prévention et/ou le traitement de diverses maladies inflammatoires (asthme, néphrite, néphropathie, hépatite, arthrite, polyarthrite rhumatoïde, rhinite, conjonctivite, colite ulcéreuse, etc), des maladies auto-immunitaires (maladie auto-immune, rejet de greffe, l'immunosuppression, le psoriasis, la sclérose en plaques etc), l'infection au virus de l'immunodéficience humaine (syndrome de l'immunodéficience humaine acquise), les maladies allergiques (dermatite atopique, urticaire, aspergillose bronchopulmonaire allergique, la gastroentérite à éosinophiles allergique, etc), la lésion de reperfusion ischémique, le syndrome de détresse respiratoire aigu, le choc accompagnant l'infection bactérienne, le diabètre sucré, la métastase cancéreuse, etc.
Matsuo Masayoshi
Nishizawa Rena
Sagawa Kenji
Shibayama Shiro
Takaoka Yoshikazu
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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