Triazaspiro[5.5]undecane derivatives and pharmaceutical...

Details Triazaspiro[5.5]undecane derivatives and pharmaceutical... Triazaspiro[5.5]undecane derivatives and pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/499 (2006.01) A61K 31/5377 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 9/02 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/04 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 27/14 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 35/04 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2394679

Triazaspiro[5.5]undecane derivatives represented by general formula (I), quaternary ammonium salts thereof, N-oxides thereof and nontoxic salts thereof, wherein each symbol has the meaning as defined in the description. Because of controlling the effects of chemokines/chemokine receptors, the compounds represented by general formula (I) are useful in preventing and/or treating various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, etc.

L'invention se rapporte à des dérivés triazaspiro[5.5]undécane représentés par la formule générale (I), ainsi qu'à des sels d'ammonium quaternaires, des N-oxydes et des sels non toxiques de ces dérivés. Dans la formule (I), chaque symbole possède la signification donnée dans la description. Du fait qu'ils régulent les effets des récepteurs d'une ou de plusieurs chimiokines, les composés représentés par la formule générale (I) s'avèrent utiles pour prévenir et/ou traiter diverses maladies inflammatoires, l'asthme, la dermatite atopique, l'urticaire, les allergies, les néphrites, les néphropathies, l'hépatite, l'arthrite, la polyarthrite rhumatoïde, etc.

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