Triazene compound, production and use thereof

C - Chemistry – Metallurgy – 12 – P

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C12P 13/00 (2006.01) C07C 29/10 (2006.01) C07C 29/147 (2006.01) C07C 29/17 (2006.01) C07C 45/29 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1145280

ABSTRACT OF THE DISCLOSURE Triazene compounds of the formula: R-CH=N-N=N-OH wherein R is alkyl, alkenyl or aryl and pharmaceutically acceptable salts thereof, have a relaxation activity on smooth muscle and a hypotensive activity; the triazines may be prepared by reacting a corresponding aldehyde of formula RCHO with hydrazine, followed by a reaction with a silylating agent and then with a nitrosating agent; triazene compounds in which R is trans, trans, trans-2,4,6(or 7)- undecatrienyl can be prepared by culturing a strain of Streptomyces aureofaciens.

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