C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
260/152, 195/86
C12P 13/00 (2006.01) C07C 29/10 (2006.01) C07C 29/147 (2006.01) C07C 29/17 (2006.01) C07C 45/29 (2006.01) C07D 309/12 (2006.01)
Patent
CA 1145280
ABSTRACT OF THE DISCLOSURE Triazene compounds of the formula: R-CH=N-N=N-OH wherein R is alkyl, alkenyl or aryl and pharmaceutically acceptable salts thereof, have a relaxation activity on smooth muscle and a hypotensive activity; the triazines may be prepared by reacting a corresponding aldehyde of formula RCHO with hydrazine, followed by a reaction with a silylating agent and then with a nitrosating agent; triazene compounds in which R is trans, trans, trans-2,4,6(or 7)- undecatrienyl can be prepared by culturing a strain of Streptomyces aureofaciens.
347130
Aoki Hatsuo
Iguchi Eiko
Imanaka Hiroshi
Kohsaka Masanobu
Okamoto Masanori
Fujisawa Pharmaceutical Co. Ltd.
Sherman
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