Triazepine derivatives as neurotrophic agents

Details Triazepine derivatives as neurotrophic agents Triazepine derivatives as neurotrophic agents

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07D 255/00 (2006.01) C07D 255/02 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2462643

This invention relates to a series of triazepines of Formula I and II, and pharmaceutical compositions containing them. The compounds of the invention have neurotrophic activity and are useful in the treatment and prevention of neuronal disorders such as Parkinson's disease, Alzheimer's disease, stroke, multiple sclerosis, amyotrophic lateral sclerosis diabetic neuropathy and Bell's palsy.

L'invention concerne une série de triazépines de formules I et II, ainsi que des compositions pharmaceutiques les contenant. Les composés de l'invention possèdent une activité neurotrophique et sont utiles dans le traitement et la prévention de troubles neuronaux, dans le cas notamment de maladie de Parkinson, de maladie d'Alzheimer, d'accident vasculaire cérébral, de sclérose multiple, de sclérose latérale amyotrophique, de neuropathie diabétique et de paralysie de Bell.

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