Triazine compounds as p13 kinase and mtor inhibitors

Details Triazine compounds as p13 kinase and mtor inhibitors Triazine compounds as p13 kinase and mtor inhibitors

C - Chemistry, Metallurgy

07

D

C07D 498/08 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2721692

Compounds of formula I(I) wherein: R1 is (II) or (III); and R2, R4, and R6-9 are defined herein, and pharmaceutically-acceptable salts and esters thereof. These compounds inhibit P13 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.

L'invention porte sur des composés de formule I (I) dans laquelle : R1 représente (II) ou (III); et R2, R4 et R6-9 sont définis présentement, et sur des sels pharmaceutiquement acceptables et esters de ceux-ci. Ces composés inhibent la kinase P13 et mTOR, et peuvent être utilisés pour traiter des maladies à médiation par la kinase P13 et mTOR, telles qu'une diversité de cancers. L'invention porte également sur des procédés de fabrication et d'utilisation des composés de cette invention. L'invention porte également sur diverses compositions contenant les composés de cette invention.

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