Triazine derivatives

Details Triazine derivatives Triazine derivatives

C - Chemistry, Metallurgy

07

D

167/216, 260/248

C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1311756

RAN 4022/14 Abstract Compounds of the formula Image I wherein A represents a grouping of the formula Image Image (a), (b) or Image (c) in which R1 and R2 each individually represent hydrogen, halogen, trifluoromethyl, nitro, amino, cyano, C1-C6-alkyl, C1-C6-alkoxy, C3-C6- -alkenyloxy, C1-C6-alkylthio, C1-C6-alkanoyl- amino, aryloxy, aryl-(C1-C6-alkyl), aryl- -(C1-C6-alkoxy), aryl-(C1-C6-alkoxy)carbonyl- amino or a group of the formula -O-CH -R3 or R1 and R2 on adjacent carbon atoms together represent a group of the formula -CH=CH-CH=CH- or -CH2-CH2-O- and R3 Lepresents hydroxy-(Cl-C4-alkyl) or vicinal dihydroxy-(C2-C5-alkyl), said aryl moiety in the above substituents being unsubstituted phenyl or phenyl substituted with at least one substituent selected from the group consisting of halogen, trifluoromethyl, Cl-C6- alkyl, Cl-C6-alkoxy, nitro and cyano, with the provisos that when A represents group (c) then R1 and R2 cannot both be hydrogen and when A represents group (c) and one of R1 and R2 represents halogen, Cl-C6-alkyl or Cl-C6- alkoxy then the other R1 and R2 cannot be hydrogen, and pharmaceutically acceptable acid addition salts of those compounds of formula I in which R1 and/or R2 represents amino, possess xanthine oxidase inhibiting activity and can be used as medicaments, particularly for the control or prevention of ischemia or gout. These compounds can be manufactured according to known methods.

553629

Affiliated with

Also associated with

Rating

Triazine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triazine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triazine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1332826