C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/53 (2006.01) A61K 39/395 (2006.01) A61M 1/36 (2006.01) A61P 37/00 (2006.01) C07D 403/12 (2006.01) C07K 1/22 (2006.01) C07K 16/24 (2006.01)
Patent
CA 2554635
Compounds containing two mono- or disubstituted triazine rings covalently linked by an organic linker, but not linked directly to each other, may be used to treat autoimmune diseases. Autoimmune diseases which are amenable to treatment with compounds of this invention include rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic (immune) thrombocytopenia (ITP), glomerulonephritis and vasculitis. The present invention also relates to reducing drug toxicity which often accompanies traditional therapies for autoimmune diseases. The compounds may also be used to bind antibody in vitro or ex vivo.
L'invention porte sur des composés contenant deux noyaux de triazine mono ou disubstitués liés par covalence par un bras organique, mais non liés directement l'un à l'autre, qui peuvent être utilisés pour traiter les maladies auto-immunes. Les maladies auto-immunes susceptibles d'être traitées par des composés de l'invention comprennent l'arthrite rhumatoïde, le lupus érythémateux systémique, la thrombocytopénie idiopathique (immune), la glomérulonéphrite et la vasculite. L'invention permet également de réduire la toxicité médicamenteuse qui accompagne souvent les thérapies des maladies auto-immunes. Les composés peuvent également être utilisés pour lier des anticorps in vitro ou ex vivo.
Abbott Shaun D.
Bienvenu Jean-Francois
Cameron Alan D.
Duceppe Jean-Simon
Ezzitouni Abdallah
Leclaire France
Prometic Biosciences Inc.
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