C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 251/22 (2006.01) A61P 43/00 (2006.01) C07D 251/16 (2006.01) C07D 251/18 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2386218
The invention relates to inhibitors of formula (I) of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms. In formula (I), each R1 and R2 is independently R3; R8; NHR3; NHR5; NHR6; NR5R5; NR5R6; SR5; SR6; SR3; OR5; OR6; OR3; C(O)R3; heterocyclyl optionally substituted with 1-4 independent R4 on each ring; or C1-C10 alkyl substituted with 1-4 independent R4; R3, R4, R5, R6, R8 are as defined in the application.
Cette invention concerne des inhibiteurs [formule (I)] d'enzymes qui se lient à ATP ou GTP et/ou qui catalysent le transfert de phosphoryle, des compositions renfermant lesdits inhibiteurs, et des méthodes d'utilisation des inhibiteurs et des compositions les renfermant. Ces inhibiteurs et les compositions qui les renferment conviennent pour le traitement de maladies ou de symptômes de maladies. L'invention porte également sur des méthodes de fabrication de composés inhibiteurs de la phosphoryl tranférase, des techniques permettant d'inhiber l'activité de la phosphoryl transférase ainsi que des méthodes de traitement de maladies ou de symptômes de maladies. Dans la formule (I), chaque R?1¿ et R?2¿ est indépendamment R?3¿; R?8¿; NHR?3¿; NHR?5¿; NHR?6¿; NR?5¿R?5¿; NR?5¿R?6¿; SR?5¿; SR?6¿; SR?3¿; OR?5¿; OR?6¿; OR?3¿; C(O)R?3¿; un hétérocyclyle éventuellement substitué par 1-4 R?4¿ indépendant sur chaque noyau; ou un alkyle en C1-C10 substitué par 1-4 R?4¿ indépendant; R?3¿, R?4¿, R?5¿, R?6¿, R?8¿ sont tels que définis dans l'application.
Armistead David M.
Bemis Jean E.
Buchanan John L.
Dipietro Lucian V.
Elbaum Daniel
Amgen Inc.
Gowling Lafleur Henderson Llp
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