Triazines as protein binding ligands

Details Triazines as protein binding ligands Triazines as protein binding ligands

C - Chemistry, Metallurgy

07

D

C07D 251/44 (2006.01) B01D 15/38 (2006.01) B01J 20/286 (2006.01) C07D 251/50 (2006.01) C07D 251/70 (2006.01) G01N 30/00 (2006.01)

Patent

CA 2611734

Compounds of the general formula (I): in which inter alia Q1 represents - NR1R3, -OR1 or -SR1 and Q2 represents -NR2R4, -OR2 or -SR2, and A represents the point of attachment to a support matrix, are useful as protein binding ligands when (a) at least one of R1, R2, R3 and R4 includes an alkyl group - CnH2n+1 in which n is greater than or equal to 7; (b) at least two of R1 , R2, R3 and R4 independently include an alkyl group -CnH2n+1 or a cycloalkyl group - CnH2n-1 in which n is greater than or equal to 4; or (c) at least three of R1, R2, R3 and R4 independently include a C1-12 alkyl group substituted by -NR5R6 or aryl.

L'invention concerne des composés ayant une formule générale (I): dans laquelle, entre autres, Q1 représente -NR1R3, -OR1 ou -SR1 et Q2 représente -NR2R4, -OR2 ou -SR2, et A représente le point de fixation à une matrice de support; ils sont utiles en tant que ligands de liaison de protéines; (a) au moins un parmi R1, R2, R3 et R4 comprenant un groupe alkyle -CnH2n+1 dans lequel n est supérieur ou égal à 7; (b) au moins deux parmi R1, R2, R3 et R4 comprenant indépendamment un groupe alkyle -CnH2n+1 ou un groupe cycloalkyle -CnH2n-1 dans lequel n est égal ou supérieur à 4; ou (c) au moins trois parmi R1, R2, R3 et R4 comprenant indépendamment un groupe alkyle C1-12 substitué par -NR5R6 ou aryle.

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