Triazole antifungal agent

Details Triazole antifungal agent Triazole antifungal agent

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A01N 43/653 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 411/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2217516

A compound having the formula: (see Formula I) [wherein Ar1 represents a phenyl which may be substituted, Ar2 represents a phenyl which may be substituted or a heterocyclic group which may be substituted, R0 represents a hydrogen atom or a lower alkyl; R1 represents a lower alkyl; R2 to R5 represent a hydrogen atom or an alkyl which may be substituted with halogen, n represents 0 to 2; p represents 0 or 1; q, r and s represent 0 to 2; A represents a 4- to 7-membered carbon ring or a 4- to 7-membered heterocyclic group]. The compound of the present invention exhibits excellent antifungal activities.

La présente invention décrit un composé de formule générale (I), dans laquelle Ar<1> représente un phényle substitué facultativement; Ar<2> représente un phényle substitué facultativement ou un hétérocycle substitué facultativement; R<0> représente un hydrogène ou un alkyle inférieur; R<1> représente un alkyle inférieur; R<2> à R<5> représentent chacun un hydrogène ou un alkyle halogéné facultativement; n est compris entre 0 et 2; p vaut 0 ou 1; r et s sont compris chacun entre 0 et 2; et A représente un carbocycle de 4 à 7 chaînons ou un hétérocycle de 4 à 7 chaînons. Le composé possède une excellent activité antifongique.

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