Triazole antifungal agents

Details Triazole antifungal agents Triazole antifungal agents

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 213/70 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2118937

The invention provides antifungal compounds of formula (I) and the pharmaceutical acceptable salts thereof, wherein R is phenyl substituted by up to 3 substituents each independently selected from halo and trifluoromethyl; R1 is C1-C4alkyl; R2 is .alpha., .beta. or .gamma.; R3 is -S(O)mR4; R4 is C1-C4 alkyl; and m is 0, 1 or 2, together with pharmaceutical compositions containing, and processes and intermediates for preparing, said compounds.

L'invention permet d'obtenir des composés antifongiques de formule (I) et leurs sels acceptables en pharmacie, où R est un phényle avec 3 substituants, choisis chacun indépendamment l'un de l'autre parmi un halogène et un trifluorométhyle; R1 est un alkyle C1-C4; R2 est alpha, bêta ou gamma; R3 est -S(O)mR4; R4 est un alkyle C1-C4; m est 0, 1 ou 2; compositions pharmaceutiques à base de ces composés; méthodes et intermédiaires pour les préparer.

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