Triazole compounds having amide linkage

Details Triazole compounds having amide linkage Triazole compounds having amide linkage

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/428 (2006.01) A61K 31/4439 (2006.01) A61P 31/10 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2404701

Compounds of the general formula (I) or pharmacologically acceptable prodrugs or salts thereof, exhibiting excellent antimycotic activity: (I) wherein Ar1 is phenyl or the like; Ar2 is phenylene or the like; X is sulfur or methylene; R1 is hydrogen or C1-3 alkyl; R2 is hydrogen or C1-3 alkyl; and R3 is optionally substituted C6-10 aryl or the like.

L'invention concerne des composés correspondant à la formule générale (I) -ou des promédicaments ou sels de ceux-ci, acceptables sur le plan pharmacologique- lesquels possèdent une excellente activité antimycosique. Dans cette formule, Ar?1¿ représente phényle ou analogue, Ar?2¿ représente phénylène ou analogue, X représente soufre ou méthylène, R?1¿ représente hydrogène ou alkyle C¿1-3?, R?2¿ représente hydrogène ou alkyle C¿1-3?, et R?3¿ représente aryle C¿6-10? éventuellement substitué, ou analogue.

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