C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/08 (2006.01) A61K 31/4196 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/12 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) A61P 43/00 (2006.01) C07D 401/08 (2006.01) C07D 403/08 (2006.01) C07D 409/08 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2580409
[PROBLEMS] TO provide a compound usable in treating diseases in which 11.beta.- hydroxysteroid dehydrogenase type 1 (11.beta.-HSD1) participates, in particular, diabetes and insulin resistance. [MEANS FOR SOLVING PROBLEMS] It is found out that a triazole derivative characterized by being substituted by a trisubstituted methyl group at the 2-position of the triazole ring or a pharmaceutically acceptable salt thereof has a potent 11.beta.-HSD1 inhibitory activity. Moreover, this triazole derivative exhibits an excellent hypoglycemic effect, which makes it usable in treating diabetes and insulin resistance.
La présente invention a pour objet un composé utilisable dans le traitement de maladies où intervient la 11.beta.-hydroxystéroide déshydrogénase de type 1 (11.beta.-HSD1), en particulier les diabètes et l~insulinorésistance. Dans un mode préféré de l~invention, ce composé est un dérivé de triazole caractérisé en ce qu~il est substitué par un groupement méthyle trisubstitué en position 2 du cycle triazole, ou un sel de qualité pharmaceutique dudit dérivé de triazole. Ledit dérivé ou l~un de ses sels présente une importante activité inhibitrice de la 11.beta.-HSD1. De plus, ledit dérivé présente un excellent effet hypoglycémique, ce qui le rend utilisable dans le traitement des diabètes et de l'insulinorésistance.
Fukudome Hiroki
Hosaka Mitsuru
Inoki Yutaka
Ishii Hirofumi
Kawano Tomoaki
Astellas Pharma Inc.
Dennison Associates
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