Triazole derivatives as cyclooxygenase (cox) inhibitors

Details Triazole derivatives as cyclooxygenase (cox) inhibitors Triazole derivatives as cyclooxygenase (cox) inhibitors

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01) A61P 7/02 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2465757

Compound of formula (I) wherein R1 is lower alkyl which is optionally substituted with halogen; R2 is lower alkoxy; R3 is lower alkoxy; X is O; Y and Z are each CH; and m is 1; or salts thereof, which are useful as a medicament for treating and preventing inflammatory pain, collagen diseases, autoimmune diseases, immunity diseases, thrombosis, cancer and neurodegenerative diseases.

L'invention porte sur un composé de formule (I) dans laquelle R?1¿ représente alkyle inférieur qui est éventuellement substitué par halogène, cyano, N,N-di(inférieur)alkylcarbamoyle, phényle éventuellement substitué par halogène ou un groupe hétérocyclique, cyclo(inférieur)alkyle, alkynyle inférieur ou N,N-di(inférieur) alkylcarbamoyle; R?2¿ représente alkyle inférieur, alcoxy amino inférieur, cyano ou 1H-pyrrol-1-yl; R?3¿ représente alkyle inférieur, alcoxy inférieur ou cyano; X représente O, S, SO ou SO¿2?; Y et Z représentent, chacun, CH ou N; et m vaut 0 ou 1. L'invention porte également sur des sels de ces composés qui sont utiles comme médicament.

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