C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/08 (2006.01) A61K 31/4196 (2006.01) C07D 249/16 (2006.01)
Patent
CA 2526712
Triazole derivatives of structural formula I are selective inhibitors of the 11.beta.-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.
L'invention porte sur des dérivés de triazole de formule structurale (I) qui sont des inhibiteurs sélectifs de la 11.szlig.-hydroxystéroïde déshydrogénase-1. Les composés sont utiles dans le traitement du diabète, tel que le diabète non insulino-dépendant (NIDDM), l'hyperglycémie, l'obésité, la résistance à l'insuline, la dyslipidémie, l'hyperlipidémie, l'hypertension, le syndrome métabolique et autres symptômes associés à NIDDM.
Aster Susan D.
Balkovec James M.
Graham Donald W.
Gu Xin
Leeman Aaron H.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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