Triazole derivatives as inhibitors of 11-beta-hydroxysteroid...

Details Triazole derivatives as inhibitors of 11-beta-hydroxysteroid... Triazole derivatives as inhibitors of 11-beta-hydroxysteroid...

C - Chemistry, Metallurgy

07

D

C07D 487/02 (2006.01) A61K 31/4196 (2006.01) A61K 31/506 (2006.01)

Patent

CA 2635211

Triazole derivatives of structural formula I are selective inhibitors of the 11.beta.-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

La présente invention concerne des dérivés de triazole de formule (I) qui sont des inhibiteurs sélectifs de la 11.beta.-hydroxystéroïde déshydrogénase-1. Les composés sont utiles dans le traitement du diabète, tel que le diabète non insulinodépendant (DNID), de l~hyperglycémie, de l~obésité, de l~insulinorésistance, de la dyslipidémie, de l~hyperlipidémie, de l~hypertension, du syndrome métabolique et d~autres symptômes associés au DNID.

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