Triazole derivatives as inhibitors of 11-beta-hydroxysteroid...

Details Triazole derivatives as inhibitors of 11-beta-hydroxysteroid... Triazole derivatives as inhibitors of 11-beta-hydroxysteroid...

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/4196 (2006.01) A61K 31/4245 (2006.01) A61P 3/10 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/08 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 413/08 (2006.01) C07D 417/08 (2006.01)

Patent

CA 2510540

Triazole derivatives of structural formula (I) are selective inhibitors of the 11.beta.-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

L'invention concerne des dérivés de triazole de formule structurelle (I) qui sont des inhibiteurs sélecteurs de la 11.beta.-hydroxystéroïde déhydrogénase 1. Les composés sont utilisés dans le traitement de diabètes, tels que des diabètes non insulino dépendant (DNID), l'hyperglycémie, l'obésité, la résistance à l'insuline, la dyslipidémie, l'hyperlipidémie, l'hypertension, le syndrome métabolique et d'autres symptômes liés aux diabètes non insulino dépendant (DNID).

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