C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/06 (2006.01) A61K 31/4245 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2625871
Triazole derivatives of structural formula I are selective inhibitors of the 11.beta.-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.
L'invention des dérivés de triazole de formule structurelle I, inhibiteurs sélectifs de la 11.beta.-hydroxystéroïde déshydrogénase-1. Les composés peuvent être employés dans le traitement du diabète, par exemple du diabète non insulino-dépendant (DNID), de l'hyperglycémie, de l'obésité, de l'insulino-résistance, de la dyslipidémie, de l'hyperlipidémie, de l'hypertension, du syndrome métabolique et d'autres symptômes associés au DNID.
Balkovec James M.
Gu Xin
Kevin Nancy J.
Waddell Sherman T.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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