Triazole derivatives as kinase inhibitors

Details Triazole derivatives as kinase inhibitors Triazole derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2662074

The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.

L'invention concerne des composés de formule (I), dans laquelle X et R1 à R5 ont les significations données dans la description et dans les revendications. Lesdits composés sont utiles en tant qu'inhibiteurs de protéine kinase, notamment en tant qu'inhibiteurs de Itk ou PI3K, pour le traitement ou la prophylaxie de troubles immunologiques, inflammatoires ou allergiques. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, la préparation de tels composés, ainsi que leur production et leur utilisation en tant que médicaments.

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