Triazole derivatives as tachykinin receptor antagonists

Details Triazole derivatives as tachykinin receptor antagonists Triazole derivatives as tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 249/06 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/4985 (2006.01) A61K 31/501 (2006.01) A61K 31/5025 (2006.01) A61K 31/505 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2483159

This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents indpendently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)

La présente invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiques qu'il permet d'obtenir, et son utilisation en tant qu'inhibiteur du sous-type NK-1 des récepteurs de la tachykinine, ainsi qu'un procédé pour le préparer et des produits intermédiaires de ce composé. Dans la formule (I): D est alkane-diyle en C¿1?-C¿3?; R?1¿ est phényle qui est éventuellement substitué avec un à trois substituants choisis indépendamment dans le groupe comprenant halo, alkyle en C¿1?-C¿4?, alcoxy en C¿1?-C¿4?, cyano, difluorométhyle, trifluorométhyle, et trifluorométhoxy; R?4¿ est un radical choisi dans le groupe comprenant (IA), (IB), (IC), (ID), (IE), (IF), (IG), et (IH).

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