C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2497971
Novel triazole derivatives of formula (Ia-c) intermediates for their preparation, pharmaceutical compositions containing them and their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-.beta.signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
L'invention concerne de nouveaux dérivés de triazole de formule (Ia-c), des intermédiaires pour leur préparation, des compositions pharmaceutiques les contenant et leur application médicinale. Les composés de cette invention sont de puissants inhibiteurs de la voix de signalisation du facteur de croissance transformant ("TGF")-.beta.. On les utilise dans le traitement de différents états pathologiques associés au TGF, notamment aux cancers et aux affections fibrotiques.
Blumberg Laura Cook
Munchhof Michael John
Pfizer Products Inc.
Sim & Mcburney
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