Triazole derivatives useful in therapy

Details Triazole derivatives useful in therapy Triazole derivatives useful in therapy

C - Chemistry, Metallurgy

07

F

C07F 9/6518 (2006.01) A61K 31/675 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2240777

The invention provides compounds of formula (I) :R1-OP(O)(OH)2, wherein R1 represents the non-hydroxy portion of a triazole antifungal compound of the type comprising a tertiary hydroxy group; or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful in the treatment of fungal infections, and have good aqueous solubility.

L'invention concerne des composés de la formule R?1¿-OP(O)(OH)¿2?, ou un sel de ceux-ci, acceptable sur le plan pharmacologique. Dans cette formule, R?1¿ représente la portion non hydroxy d'un composé antifongique triazole du type comprenant un groupe hydroxy tertiaire. Les composés de l'invention sont utiles dans le traitement des infections fongiques et possèdent une bonne solubilité aqueuse.

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